Abstract The prognosis of recurrent malignant peripheral nerve sheath tumors (MPNST) is dismal, with surgical resection being the only definitive salvage therapy.Treatment with chemoradiation approaches has not significantly improved patient outcomes.Similarly, trials of therapies targeting MPNST genomic drivers have thus far been unsuccessful.Impr
Abstract Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture.However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability.To overcome this, we engineered mammalian cells to rapid
In this study, zein-based gluten-free model dough (Z dough) was prepared with zein, corn starch, and wormwood gum.Based on the flour quality test, the kneading torque, water composition and protein distribution of the zein simulated dough with different lactic acid content were compared when finish dough (torque up to 1.1 Nm; set as ZS dough) and k
Innovations are required in urban infrastructures due to the pressing needs for mitigating climate change and prevent resource depletion.In order to address the slow pace of innovation in urban systems, this paper analyses factors involved in attempts to introduce novel sanitary systems.Today new requirements are important: sanitary systems should